Applications for α-lactalbumin in human nutrition
نویسندگان
چکیده
منابع مشابه
Targeted Vaccination against Human α-Lactalbumin for Immunotherapy and Primary Immunoprevention of Triple Negative Breast Cancer
We have proposed that safe and effective protection against the development of adult onset cancers may be achieved by vaccination against tissue-specific self-proteins that are "retired" from expression at immunogenic levels in normal tissues as we age, but are overexpressed in emerging tumors. α-Lactalbumin is an example of a "retired" self-protein because its expression in normal tissues is c...
متن کاملSerum metabolomic profile in genetically modified cows carrying human α-lactalbumin gene
The present study aimed to investigate the serum metabolomic profiles in genetically modified cows carrying and expressing human lactalbumin α (LALBA) and non‑LALBA cows, and identify altered metabolic characteristics following the genetic modification. Serum biochemistry indexes were measured according to protocols recommended by International Federation of Clinical Chemistry. The metabolomic ...
متن کاملProbing the urea dependence of residual structure in denatured human α-lactalbumin
Backbone (15)N relaxation parameters and (15)N-(1)H(N) residual dipolar couplings (RDCs) have been measured for a variant of human alpha-lactalbumin (alpha-LA) in 4, 6, 8 and 10 M urea. In the alpha-LA variant, the eight cysteine residues in the protein have been replaced by alanines (all-Ala alpha-LA). This protein is a partially folded molten globule at pH 2 and has been shown previously to u...
متن کاملPhysicochemical properties of human lactalbumin.
Proteins of the same kind in human milk and cow's milk have different properties. Mellander (1947) reports differences in phosphorus content and the amount of carbohydrates of casein and that the casein of cow's milk is more easily digested by proteolytic enzymes in vitro than that of human milk. Kiyosawa, Ryoki & Maeno (1961) observed a marked difference in the solubility of casein and the tur...
متن کاملStructure and function of human α-lactalbumin made lethal to tumor cells (HAMLET)-type complexes.
Human α-lactalbumin made lethal to tumor cells (HAMLET) and equine lysozyme with oleic acid (ELOA) are complexes consisting of protein and fatty acid that exhibit cytotoxic activities, drastically differing from the activity of their respective proteinaceous compounds. Since the discovery of HAMLET in the 1990s, a wealth of information has been accumulated, illuminating the structural, function...
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ژورنال
عنوان ژورنال: Nutrition Reviews
سال: 2018
ISSN: 0029-6643,1753-4887
DOI: 10.1093/nutrit/nuy004